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Dr Katherine James

Department: Applied Sciences

Qualifications

  • Computer Science PhD July 31 2011
  • Bioinformatics MRes September 01 2006
  • Molecular Biology BSc (Hons) June 01 2000

Key Publications

  • Please visit the Pure Research Information Portal for further information
  • High intrinsic hydrolytic activity of cyanobacterial RNA polymerase compensates for the absence of transcription proofreading factors, Riaz-Bradley, A., James, K., Yuzenkova, Y. 20 Feb 2020, In: Nucleic Acids Research
  • Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase, Forrest, D., James, K., Yuzenkova, Y., Zenkin, N. 6 Jun 2017, In: Nature Communications
  • Deep sequencing approaches for the analysis of prokaryotic transcriptional boundaries and dynamics, James, K., Cockell, S., Zenkin, N. 1 May 2017, In: Methods
  • Misincorporation by RNA polymerase is a major source of transcription pausing in vivo, James, K., Gamba, P., Cockell, S., Zenkin, N. 1 Feb 2017, In: Nucleic Acids Research

Research Themes and Scholarly Interests

My research focuses on the analysis and systematic integration of largescale omics and sequence data in order to characterise highly complex cellular systems and generate novel, testable hypotheses.  My current projects involve the application of advanced bioinformatic approaches to the analysis of sequence data with a focus on wildlife transcriptomics and metagenomics, and the development of probabilistic functional integrated networks for comparative interactomics between species.


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